Hi, I have done a shoot with a big tiger, and I can tell you now, your actors will NOT be sharing the space with the animal.
You have to think in terms of post production solutions to this.
A Tiger is about the most dangerous animal on the planet, and although with a good trainer can be well behaved, having strangers with them in a confined space could result in an accident happening.
We had a room in a house boarded up (including the windows) and the canera crew were inside a metal cage. The actors were aded into the set AFTER the tiger had left.
goof luck.